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KMID : 0391419970070010029
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Korean Journal of Lipidology
1997 Volume.7 No. 1 p.29 ~ p.46
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Pathophysiology and Molecular Mechanism of Visceral Fat Syndrome
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Yuji Matsuzawa
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Abstract
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-Abstract-
Contemporary civilized countries provide an increasing number of opportunities for
overeating and decreased muscular exercise, where common health problems are closely
correlated to this over nutritional state and its typical consequence, obesity. Therefore,
obesity has become one of main targets for medical researches with respect to
preventive medicine. Previous studies on morbidity of obesity have indicated that the
severity of complications such as glucose intolerance or lipid disorders does not
necessarily correlate to the extent of body fat accumulation, but closely related to body
fat distribution. Several classifications of obesity concerning body fat distribution have
been proposed in order to clarity possible mechanism of morbidity of obesity. A
Japanese ancient artist had showed great insight into the morbidity of obesity in 800
years age and he painted a picture of an obese woman with the title of "a very obese
woman who can hardly walk (Fig. 1) in the Japanese old picture scroll "Yamal-Zoshi"
which means a scroll for various morbid states. This artist already noticed that this
type of obesity was considered unhealthy and morbid. In 1947, Vague first reported that
incidence of metabolic complications among equally obese subjects may differ depending
on their physique. He differentiated between android obesity in which fat is likely to
accumulation in the brachium and gynoid obesity in which fat accumulation occur in the
femoral region. He showed that morbidity is higher in android type than in gynoid type.
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